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However, controversy still exists as to whether it is best to therapeutically promote or inhibit GIP action for beneficial effects on glycemic control and body weight [[929], [930], [931]] as both GIPR agonists [932] and antagonists [933,934] have decreased body weight in preclinical studies as individual treatments, but also to induce synergistic body weight loss when combined with GLP-1R agonists

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By raising GABA levels, L-theanine subsequently triggers the release of key mood-regulating monoamines, including dopamine and serotonin, in critical brain regions like the prefrontal cortex and the hippocampus