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Plasma levels of pro- and anti-inflammatory cytokines were increased in wild-type (WT) but not in TLR4-deficient (Tlr4/) mice, while GLP-1 secretion could be abolished when STC-1 cells were exposed to LPS in the presence of a TLR4 antagonist (TAK-242)

From its origins as a medication primarily indicated for type 2 diabetes mellitus (T2DM), Semaglutide has emerged as a candidate with immunomodulatory properties that may hold relevance for autoimmune conditions like lupus

Grasbeck R

Additionally, the same study reported a decrease in cigarette smoking among participants who were smokers, suggesting potential cross-substance benefits of GLP-1RAs in this population (Hendershot et al., 2025)