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Undergo rigorous quality verification precisely because administration route and purity interact to determine research reproducibility

doi: 10.1038/s41467-020-17181-w 55 ZhiweiYTaiyanYXuWKelinMTianlaiWBoyuWet al

The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression

For objective data, track your biomarkers (like liver enzymes or hs-CRP) or monitor your body composition changes with a DEXA scan