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Animals were placed in metabolic cages prior to the start of the study and time zero blood and urine samples were collected

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What MTHFR Does and What Goes Wrong When It Doesn't MTHFR (methylenetetrahydrofolate reductase) catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-methyltetrahydrofolate (5-MTHF) the predominant circulating form of folate and the methyl donor required by methionine synthase (MTR) to convert homocysteine back to methionine