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1H NMR (D 2 0, 500 MHz) 5(ppm) 8.76(s, IH, FA H-7), 7.68(d, 2H, FA H-12&H16), 6.8(d, 2H, FA H-13&H15), 4.71(dd, IH, Asp H-2), 4.64(s, 2H FA H-9), 4.41(dd, IH, D-Glu H-2), 4.3(dd, IH, Cys H-2), 4.1(dd, Dpr H-2),3.72(dd, IH, Dpr H- 3A), 3.52(dd, IH, Dpr H-3B), 2.89(dd, IH, Cys H-3A), 2.85(dd, IH, Cys H-3B), 2.81(dd, IH, Asp H-3A), 2.62(dd, IH, Asp H-3B), 2.44(dd, 2H, D-Glu H-4), 2.27 (m, IH, D-Glu H-3A), 2.08(m, IH, D-Glu H-3B)

Satiety and Nausea: Both activate satiety centers in the hypothalamus, which may contribute to the nausea commonly seen during drug initiation or dose escalation

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