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The clinical features strongly resemble classical EDS (cEDS) with two key differences: (1) the absence of atrophic scarring and (2) autosomal recessive inheritance
According to the literature, in experimental mice with allergic rhinitis treated with berberine, serum IgE, GATA-3, IL-4, and IL-13 mRNA levels, as well as tissue eosinophil numbers, were significantly reduced
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