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T-lymphocytes arrive at the wound site in the late stages of inflammation and appear to coordinate tissue remodeling ( Figure 1 Proliferative phase The wound enters the proliferative phase as inflammation subsides and macrophages change to an alternate activated or anti-inflammatory phenotype

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The phase 2 dose-ranging trial (NCT02970942) included 320 individuals with histologically proven MASH and hepatic fibrosis F1-F3, randomizing them 3:3:3:1:1:1 to daily subcutaneous administration of semaglutide 0.1, 0.2, or 0.4 mg, or placebo for 72 weeks [18]