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Protein requirements should generally be calculated using a clinically appropriate target body weight rather than current weight in patients with obesity, as using current weight could result in unrealistically high and impractical protein targets

Onset and dosing Both medications typically start at a low dose that is increased slowly to reduce side effects

Tirzepatide users on insulin or sulfonylureas who receive a short steroid course may need temporary insulin dose adjustments

Patients could start with injectable tirzepatide for aggressive weight loss, then transition to oral orforglipron for convenient long-term maintenance