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Using this mechanism through more targeted psychotropic action may then be used to develop agents that further ameliorate psychiatric symptom expression

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Continuous MT-1 administration beyond 3 weeks causes melanocortin receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding

MR-PRESSO applies a leave-one-out approach to identify the genetic variant(s) differentially driving the associations [41], i.e., outliers, and provide a corrected estimate after removing the outliers [42]