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Potential Skin Benefits of Cannabis Interestingly, while smoking cannabis might have drawbacks for skin health, certain cannabis compounds show promise for dermatological applications: CBDs Anti-Inflammatory Properties Cannabidiol (CBD) has garnered attention for its anti-inflammatory effects when applied topically: Sebum Regulation : Early research suggests CBD might help normalize oil production Acne Reduction : A 2014 study in the Journal of Clinical Investigation found that CBD can reduce excess oil production