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The IGF Binding Protein Problem To understand why IGF-1 LR3 matters, you need to understand IGFBPs

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In particular, they target areas that are important for homeostatic feeding, such as the hypothalamus, and for hedonic responses, such as the nucleus accumbens (NAc), ventral tegmental area (VTA), and laterodorsal tegmental area (LDTg) ( PPG gene is also expressed in the olfactory bulb (Merchenthaler et al., 1999), amygdala, striatum, and hippocampus (Vallof et al., 2019a)

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