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Similarly, a systematic review by Arab (2024) synthesised findings from 37 observational studies, encompassing a total sample of 591,223 individuals, and reported that adherence to healthy dietary patternssuch as the Mediterranean diet and high-quality dietswas associated with a lower prevalence of insomnia symptoms [145]

Besides, several studies in mice showed that GLP-1 and GLP-1RAs stimulate IGF-1 receptor (IGF-1R) expression [10], [11], favor bone metabolism homeostasis [8], [12] and even directly cross-activate the IGF-1R [13]

& Jepsen, S

For someone who needs to reach higher maintenance doses, this structure saves hundreds over time