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Some women need more (4,000-5,000 IU) and some need less if already in range

Cardiovascular outcome trials evaluating novel agents that target multiple pathways including combinations of GLP-1 agonism, GIP agonism, glucagon receptor agonism and amylin analogues are ongoing and will help define the next generation of obesity treatments

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6.1 Autonomic nervous system regulation of the intestinal microenvironment The autonomic nervous system (ANS), comprising sympathetic and parasympathetic (primarily vagal) branches, exerts profound regulatory effects on gastrointestinal physiologyand thereby shapes the intestinal microbial ecology