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While not formally recognized by conventional medicine, its thought that ongoing stress and a lack of recovery can disrupt cortisol production, leading to symptoms like fatigue, brain fog, and anxiety

The effects are most pronounced in patients who pair peptide therapy with appropriate nutrition, resistance training, and sleep optimization

J Clin Lab Anal 30(5):506509 Liang C et al (2015) A subchronic oral toxicity study on Pyrroloquinoline quinone (PQQ) disodium salt in rats

Excessive and prolonged stimulation of the somatotropic axis could theoretically induce effects similar to acromegaly: fluid retention, arthralgia, carpal tunnel syndrome, insulin resistance, and potentially an increased risk of proliferation of certain IGF-1-sensitive tumor cells