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Efficacy and safety of polyethylene glycol loxenatide monotherapy in type 2 diabetes patients: a multicentre, randomized, double-blind, placebo-controlled phase 3a clinical trial

It reduced the expression of BAX (a pro-apoptotic protein) and increased Bcl-2 (an anti-apoptotic counterpart), lowering the BAX/Bcl-2 ratioan established marker of cell death susceptibility

The key molecules associated with the former include xCT, GSH, GPX4, intracellular labile iron, and ferroptosis-inhibitory pathways