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A recent multicentre placebo-controlled trial of liraglutide efficacy in adolescents and children with PWS without diabetes showed that although adolescents treated with liraglutide 3 mg had lower hyperphagia scores at week 52, changes in BMI standard deviation score from baseline to week 16 and week 52 did not significantly differ (38)

Obesity treatment follows similar logic

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Therefore, the inflammasome pathway serves as one of the critical immunological bridges through which oral microbiota influences the intestinal environment and health, and its precise regulation is essential for maintaining mucosal homeostasis