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Studies investigating the relationship among smoking time, smoking volume, and UC are thus necessary

Factsheet: Air pollutants particulate matter

Known side effects include: High risk of addiction Mouth and gum irritation Insomnia and poor-quality sleep Gastrointestinal issues, including nausea, acid reflux and bloating Elevated heart rate and blood pressure Oral, facial, and body-wide swelling from an allergic response to ONPs, which requires urgent medical attention Altered mental status, tremors, restlessness, headache and more severe symptoms of nicotine toxicity due to overdose Withdrawal symptoms that include cravings, irritability, restlessness, nausea, dizziness, difficulty concentrating, sleep disruption and anxiety

It could also be further improved by the inclusion of biological factors involved in material degradation in vivo, such as enzymatic activity, microbial colonization, or changes in saliva pH