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GLP-1 therapy is ideal for adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related health condition, who have struggled with other weight loss methods

A clinical trial on Orlistat with 237 participants reported that 56% of individuals reported side effects, with 59.2% being GI issues such as bloating, cramping, and diarrhoea

The ATTAIN program encompasses multiple Phase 3 trials in obesity (ATTAIN-1, ATTAIN-2, ATTAIN-3, ATTAIN-MAINTAIN), while the ACHIEVE program covers type 2 diabetes indications (ACHIEVE-1 through ACHIEVE-5, plus regional studies)

10.1111/liv.70407 107 PieraliceS.AmendolaraR.BernaV.ManganaroG.ZurruA.D'OnofrioL.et al (2025)