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Short-acting agents, such as exenatide and lixisenatide, exert pronounced meal-time fullness primarily through delayed gastric emptying, while long-acting formulations including liraglutide, dulaglutide, and semaglutide sustain a more persistent satiety tone via direct activation of brain receptors

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Their integration into clinical guidelines has the potential to transform HFpEF care, improving patient outcomes and alleviating healthcare burdens globally.

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