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(2024) showed that GHRP-6 prevented doxorubicin-induced myocardial and extra-myocardial damage in rats by attenuating pro-oxidant activity, enhancing antioxidant reserves, protecting mitochondrial ultrastructure, and upregulating the anti-apoptotic gene Bcl-2

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The peptide releases acetyl-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline), an anti-inflammatory fragment that reduces fibrosis and modulates inflammatory responses

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In HFD-fed mice, an increase in gut microbiota alpha diversity was observed based on the ACE, Chao, Simpson, Shannon, and Sobs indices

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et al.) (Oxford University Press, 2005)

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