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Considering that metformin-induced mitochondrial complex I inhibition impairs NADH oxidation and elevates NADH levels, these transcriptional changes probably represent a compensatory adaptation to restore redox homeostasis by enhancing NADPH generation

In addition, microglial activation may lead to alterations in glutamatergic neurotransmitters, which are involved in the pathophysiology of depression [7,9]

I dont yet have direct clinical experience at this dose, but the signal of dysesthesia certainly deserves attention

These include medication costs, access issues, side effects like nausea, or if youre planning on becoming pregnant