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Moreover, NGAL binds to the MMP-9, slows its degradation, and enhances collagen degradation.133 Plasma NGAL at discharge predicted 30-day outcomes in patients admitted for acute HF even more strongly than did NT-proBNP.134 In the TOPCAT biomarker sub-study, NGAL level tended to be associated with death or HF admission but this association lost significance upon multiple comparison ( Table 3 ).116 Cystatin-C Cystatin C (CysC) is secreted by nucleated cells at a constant rate, filtered and reabsorbed by the glomeruli, and then completely decomposed by intact renal tubules.134 CysC provides a more sensitive and accurate method for estimated glomerular filtration rate (eGFR) measurement: serum CysC reflects the GFR, while urine CysC reflects the degree of renal tubular damage

[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Linke D., Donix L., Peitzsch C., Erb H.H.H., Dubrovska A., Pfeifer M., Thomas C., Fuessel S., Erdmann K

Th17 cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications

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