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GLP-1's Impact on Appetite-Regulating Hormones: Leptin and Ghrelin Leptin resistance occurs when chronically elevated insulin and inflammatory markers suppress your brain's ability to sense fullness signals

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Many women report that once cravings calm down and they feel full longer, their emotional eating becomes much easier to manage

This metabolic shift creates an opportunity for patients with pre-existing hypothyroidism: as weight normalizes, insulin resistance often improves dramatically, and thyroid hormone requirements may decrease