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Cells were cultured in a 5% CO 2 incubator at 37C, and the medium was changed every day

The protocols described here are in alignment with the Declaration of Helsinki and were approved by the Ethics Committee of the German Sports University Cologne (012/2024)

1-MX supplementation reduced escape latency by 39% in young animals and 27% in aged animals compared to controls (both p 95% of that amount via caffeines initial metabolism to paraxanthine [11, 12] ( Fig 1 )