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The GIP gene product has a 21 amino acid signal peptide (UniProt P09681) that targets the protein to rough endoplasmic reticulum (rER) and is cleaved by signal peptidases

Its critical to be informed about these potential side effects and seek a healthcare professional for advice

If you are considering GLP-1 therapy or currently experiencing diarrhea, discussing your genetic predispositions with your provider can inform whether slower titration, dose adjustment, or alternative formulations (such as compounded oral or injectable options from PlexusDx) might optimize your tolerance

Activation of Gq phospholipase C (PLC) inositol triphosphate (IP3) + diacylglycerol (DAG) mobilization of intracellular calcium stores exocytosis of GH granules