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Novo Nordisk also recently started recruiting participants to the EVOKE trial program (phase III) expected to end in 2024, in which the effectiveness of oral semaglutide in the treatment of early Alzheimers disease will be assessed by measuring changes in clinical dementia rating, daily activity, mild cognitive impairment and mini-mental state examinations and other secondary outcome measures (NCT04777409, NCT04777396)

Microbial-derived peptides and polysaccharides promote the expansion of intestinal regulatory T cells (Tregs) and their production of anti-inflammatory IL-10, whereas segmented filamentous bacteria (SFB) drive Th (T helper) 17 differentiation and their production of proinflammatory IL-17 [40, 41]

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