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When side effects remain intolerable after six or more weeks at a stable dose, a provider-guided reduction or a medication switch may be appropriate

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Gentle Skincare: Use mild cleansers and moisturizers as recommended

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"Next-generation incretin-based therapies: exploring multi-receptor agonism in metabolic disease." Journal of Endocrinology

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By the end, people on the higher orforglipron dose lost almost 18 pounds, or about 8 percent of their starting weight

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