Pharmacokinetics: Bioavailability: ~90% Half-life: ~2430 hours Metabolism: Minimal hepatic metabolism Excretion: Mainly renal Adverse Effects: Headache Nausea Abdominal pain Diarrhea Interesting Fact: Unlike older prokinetic agents (like cisapride), prucalopride has high receptor selectivity, reducing the risk of cardiac arrhythmias a major safety improvement
PlexusDx GLP-Squared Injection combines compounded semaglutide and tirzepatide into a single formulation, at $289/mo month-to-month, or from $249/mo on the 6-month plan, targeting multiple receptor types to prevent adaptation
How Important Are Pre- and Post-Operative IV Therapies
Before Your Treatment Comprehensive labs including fasting glucose, HbA1c, lipids, metabolic panel, and thyroid are drawn before initiating Bring a complete list of current medications GLP-1 agents interact with several drug classes Disclose personal and family medical history in detail Begin keeping a food/activity journal your provider will use this to personalize your protocol After Your Treatment Start with the lowest dose and titrate slowly to minimize GI side effects (nausea, constipation) Stay well hydrated GLP-1 medications reduce the sensation of thirst Eat small, balanced meals avoid high-fat, high-sugar foods that worsen nausea Take protein intake seriously protect muscle mass during caloric restriction Monthly check-ins and labs are standard
