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this is the most important contraindication Severe uncontrolled diabetes , GH antagonizes insulin and can worsen glycemic control Active proliferative diabetic retinopathy Pregnancy or breastfeeding Pituitary disorders or recent pituitary surgery Anyone considering tesamorelin should have a baseline workup that includes IGF-1, fasting glucose, HbA1c, a lipid panel, and a careful medical history, not just to establish baselines for monitoring, but to confirm tesamorelin is mechanistically the right tool before starting

Semaglutide can help improve insulin resistance, one of the root causes of PCOS, leading to better blood sugar control and hormonal balance

doi: 10.1016/j.annonc.2020.02.016 12

2008 Oct 15;478(2):154-60