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Controlled clinical trials lasting 12 weeks with commercially available rhIGF-1 have shown safety and demonstrated benefits for PMS symptoms, improving social withdrawal, repetitive behaviors, hyperactivity, and sensory reactivity (147, 148) (Figure 2)

Real-time PCR was conducted for amplification with specific primers for the chondrogenic markers COL2A1 (Forward: 5-TTCAGCTATGGAGATGACAATC-3 and Reverse: 5-AGAGTCCTAGAGTGACTGAG-3), ACAN (Forward: 5-AGCCTGCGCTCCAATGACT-3 and Reverse: 5-TAATGGAACACGATGCCTTTCA-3), and SOX9 (Forward: 5-TTCCGCGACGTGGACAT-3 and Reverse: 5-TCAAACTCGTTGACATCGAAGGT-3)

55 FujiwaraY.MiyazakiW.KoibuchiN.KatohT

Note on insurance: For branded GLP-1s, prescriptions may be covered if filled at your pharmacy, depending on your insurance carrier