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It is also worth pointing out that some of the fastest-growing and most dangerous addictions today are not substance-based at all but relate to behaviours such as gambling, pornography, and computer gaming

Massachusetts bans all vaping products for 4 months in the toughest state action taken yet Massachusetts has banned the sale of all vaping products for four months, the strongest measure imposed by any state in the fight against vaping-related illnesses

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A solution to the shortcoming would be to enroll age and sex-matched nonsmoker subjects as control, but encouraging healthy, non-smoking participants to smoke would raise controversy over ethical background and recruitment of such control group could be very difficult