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Evidence is presented that ATF4-mediated upregulation of GSH causes T315I-Bcr-Abl-32D cells to be less sensitive to JMF4073

Studies on mice, where the RFK gene was intentionally deactivated, resulted in embryo death before day 7.5 of gestation, supporting the notion that RFK deficiency could be fatal [31]

The Phase 3 SURMOUNT trials, which enrolled over 6,000 participants, did not exclude patients taking antioxidant supplements (including glutathione precursors like N-acetylcysteine)

b , Top 5 enriched functional terms for the 1501 differentially expressed genes that were upregulated following GLP-1MK-801 treatment