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Schiaffino S, Mammucari C

The ice crystal formation during freezing physically tears apart the protein chains that give tirzepatide its biological activity

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Case presentation A 17-year-old Asian male individual with a known diagnosis of PraderWilli syndrome (confirmed by multiplex ligation-dependent probe amplification at age 15 years) presented to the emergency department with acute respiratory distress, generalized edema, and decreased urinary output