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Certain gut bacteria, including Bacteroides , Bifidobacterium , Prevotella , Faecalibacterium , Lactobacillus , and Parabacteroides , ferment indigestible polysaccharides into short-chain fatty acids (SCFAs)such as butyrate, acetate, and propionatewhich enhance epithelial barrier integrity and reduce gut permeability, thereby preventing microbial translocation to extraintestinal tissues [100, 101]

Reduced appetite often leads to reduced hydration, which decreases saliva and increases dental risks

Hepatocellular proliferation in ibuprofen-treated mice