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If you just needed to lose weight, you were on your own and without insurance, these drugs can cost hundreds of dollars a month

Pharmacometabolomics: Implications for clinical pharmacology and systems pharmacology

Rosenstock predicts that orforglipron and other similar small-molecule pills will eventually form the backbone of mainstream diabetes treatment, a role played today by the older glucose-lowering drug metformin: I can see these molecules as a first-line therapy, he says, prescribed to patients from day one. New Treatment Targets Drug developers are also racing to devise medications that drive even greater weight loss and offer more comprehensive overall health benefits, primarily by testing new agents that affect more than just the GLP-1 hormone receptor

DZIC is supported by a Department of Medicine, University of Toronto Merit Award and receives support from the CIHR, Diabetes Canada and the Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research