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Role of oncometabolites in modulating the epigenetic landscape of cancer cells Concerning the epigenetic alterations associated with oncometabolites, it has been shown that D-2HG accumulation, an event that is coupled with -KG depletion, inhibits histone lysine demethylases (KDMs), giving rise to histone hypermethylation, epigenetic programming, and acquisition of additional mutations [27]

In the present study also, using SDS-PAGE and immunofluorescence microscopy, we have confirmed the increased expression of GSTA4-4 in GSH-depleted cells treated with ASA

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ATCC CCL-2), Vero (female African green monkey kidney