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A similar hydrogen bond has been reported between Tyr433 of the lid loop and Asn400 in HpGGT (West et al., 2013)

However, early Bydureon required mixing a powder with a liquid in a syringe (a bit cumbersome), and it sometimes caused injection-site nodules (a small lump under the skin due to the depot)

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In some cases, adjusting the medication may be enough