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Also, 30- to 40-year follow-up data from the International Childhood Cardiovascular Cohort Consortium have revealed consistent links between childhood obesity and early mortality from cardiovascular diseases, cancers, abnormal lipid metabolism and diabetes in adulthood [233,234,235,236] Nonetheless, the seven cohorts in this consortium reside in high-income countries (US, Australia and Finland), thus, critical data from middle- and lower-income countries are lacking [237]

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Moreover, the sustained release capability of azelaic acid-loaded NLCs would be advantageous for topical drug delivery due to the prolonged localized drug deposition within the skin layers (Tangau et al., 2022)

GPX1 is ubiquitously expressed and found in both the cytosol and mitochondria