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doi: 10.3390/ijerph13050465 Summary Keywords E-cigarettes, dopamine, glutamate, glutamine, GABA, serotonin Citation Alasmari F, Crotty Alexander LE, Hammad AM, Bojanowski CM, Moshensky A and Sari Y (2019) Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurotransmitters in the Frontal Cortex and Striatum of C57BL/6 Mice

Within the first 15 minutes to an hour, you will notice early signs

Hyperthermia is often a symptom of serotonin syndrome (see below) and can result in hyperkalemia, heart arrhythmias, acidosis, coma, and multiple organ failure

This means speaking with a pharmacist or obtaining a prescription from a GP or nurse practitioner, depending on your circumstances and nicotine requirements