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The improvement of the microvascular network enhances nutrient and oxygen supply as well as waste removal, accelerating the inflammatory and proliferative phases of healing

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A study of children with concussion showed that the structural connectome of those with concussion differed to those of uninjured controls but not to those with OI, suggesting that some differences in brain imaging metrics reflect a general injury experience rather than brain-injury specific outcomes 33

Urine organic acid analysis in holocarboxylase synthetase deficient patients will show elevated levels of lactate, 3-hydroxyisovaleric acid, 3-hydroxypropionic acid, 3-methylcrotonic acid, methylcitric acid, and tiglylglycine