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Materials and methods Ethics statement The ethical approval for this study has been granted by the Independent Ethics Committee of the IRCCS University Hospital Company of Bologna, Policlinic of SantOrsola, Italy (number: 39/2013/U/Tess)

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Consult your GP if you experience unexplained weight gain (particularly facial and abdominal), persistent hypertension, easy bruising, purple stretch marks, muscle weakness, or mood changes