if you smoke cigarettes What Happens to Your Body, When Take a Puff of a Cigarette? Smoking Safety – Illinois Fire

Specific genetic conditions, such as Fanconi Anemia and Dyskeratosis Congenita, also elevate the risk of head and neck cancers, including throat cancer ( National Institute of Health )

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[240] [241] Preclinical studies have also produced findings of sex-dependent differences in drug response to amphetamine

#4 I dont see any reason why in wouldn't work if wired direct to the battery with sufficient gauge wire and as mentioned an inline fuse would be a good idea