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125127 When pyruvate kinase is deficient or dysfunctional, there is an increased reliance on alternative pathways for energy production leading to increased breakdown of ATP and subsequent accumulation of adenosine monophosphate

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The sequential methylation of As(III) by S- adenosyl-methionine to yield in turn the mono-, and di-methyl derivatives (and further the incorporation of the third methyl group and the generation of the haemolytic toxin trimethyl-arsine) also involves (costs) the oxidation of a further equivalent of reduced glutathione