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2 T1D as an autoimmune disease marked by a breakdown of central and peripheral tolerance and activation of autoreactive T cells Studies quantifying the link between genetic predisposition associated with T1D and cell-type-specific transcriptional signatures have shown that immune cells are the cell type most associated with T1D ( 2.1 The critical role of the thymus gland and regulatory T cells in autoimmunity In healthy individuals, the thymus plays a critical regulatory role in preventing various autoimmune diseases ( Figure 2 )