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doi: 10.1186/s13098-025-01888-1

Additionally, biotin assists in the breakdown of carbohydrates, fats, and proteins and plays a key role in boosting energy and metabolism

Whether that matters clinically depends on the patient: for a younger patient with muscle to spare, the trade-off may be acceptable

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above