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Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, et al

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial Summary: This Phase 1b trial assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of co-administering once-weekly subcutaneous cagrilintide (at various doses) with semaglutide 2.4 mg in participants for weight management

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Adrenergic stimulation can increase myocardial oxygen consumption, lead to the downregulation of -adrenergic receptors, and reverse adrenergic G protein coupling, resulting in impaired myocardial contractility and septic cardiomyopathy, particularly during prolonged administration [31, 32]