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There was also a significant increase in three synaptic markers, namely PSD95, GAP 43, and synaptophysin in VPA and TSA treated rat cortical neurons

These changes could potentially enhance the potency of IGF-1 LR3, although possibly shortening its active duration

The transcription factors (TF) E2F7 (JASPAR ID: MA0758.1) and E2F8 (JASPAR ID: MA0865.2) can bind to the region encompassing the DML a (chr17: 34283605), while E2F6 (JASPAR ID: MA0471.2) and TFDP1 (JASPAR ID: MA1122.1) can bind to the complementary region of this DML in the minus strand