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The most frequent dosing error is confusing reconstitution concentration with total vial content: a 5mg vial reconstituted with 2ml bacteriostatic water yields 2.5mg/ml, meaning a 200mcg dose requires 0.08ml, not 0.2ml drawing 0.2ml delivers 500mcg, a 2.5 overdose

[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

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