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This complexity and the broad spectrum of symptoms make managing and treating long COVID particularly challenging, underscoring the need for innovative approaches and therapies

3.6 The three-dimensional crystal structure of MSA-DH To further investigate the molecular mechanism and cofactor utilization of MSA-DH, the X-ray protein structure was determined at 2.6 (data collection and refinement statistics in Supplementary Table S1)

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This mechanism implies a concomitant mitochondrial reduction of NAD + to NADH, associated with malate oxidation to OAA, cytosolic oxidation of NADH to NAD + , and reduction of oxaloacetate to malate