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Studies demonstrate that exogenous MUFAs, such as exogenous oleic acid (OA) and palmitic oleic acid (POA), can replace PUFAs in the plasma membrane, reducing their sensitivity to oxidation, and thereby inhibiting ferroptosis caused by erastin and RSL3

Thus, the scarce human studies performed so far, regardless of all of the limitations in some of them (i.e., they lacked a large sample size, ethnic variation, and a sham control group), encompassed a wide range of investigations (i.e., ulcerative colitis [65], knee pain [263], and interstitial cystitis [264])

Using in vitro renal tubular cells and in vivo mice models of carboplatin-induced renal injury, Sue et al